The polybasic region in Gαi proteins: Relevant or not? Insights from Gαi<sub>3</sub> research.

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作者： Beata,Rysiewicz ^[1] ; Ewa,Błasiak ^[2] ; Marta,Dziedzicka-Wasylewska ^[3] ; Agnieszka,Polit ^[4]

作者单位： Department of Physical Biochemistry, Faculty of Biochemistry Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland. Electronic address: beata.rysiewicz@uj.edu.pl. ^[1] Department of Physical Biochemistry, Faculty of Biochemistry Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland. Electronic address: ewa.blasiak@uj.edu.pl. ^[2] Department of Physical Biochemistry, Faculty of Biochemistry Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland. Electronic address: marta.dziedzicka-wasylewska@uj.edu.pl. ^[3] Department of Physical Biochemistry, Faculty of Biochemistry Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, Poland. Electronic address: a.polit@uj.edu.pl. ^[4]

关键词 Dopamine D(2) receptor GPCR Gαi(3) subunit Heterotrimeric G proteins Intracellular cAMP levels Polybasic motif Protein-lipid interaction

主题词信号传导(Signal Transduction);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);异源三聚体GTP结合蛋白质类(Heterotrimeric GTP-Binding Proteins);细胞膜(Cell Membrane)

DOI 10.1016/j.cellsig.2024.111138

PMID 38467243

发布时间 2024-04-09

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