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A Self-Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer.

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第一作者： Ying,Liu

第一单位： Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.;School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.

作者： Ying,Liu ^[1] ; Babatunde O,Okesola ^[2] ; David,Osuna de la Peña ^[1] ; Weiqi,Li ^[3] ; Meng-Lay,Lin ^[4] ; Sara,Trabulo ^[4] ; Marianthi,Tatari ^[4] ; Rita T,Lawlor ^[5] ; Aldo,Scarpa ^[5] ; Wen,Wang ^[3] ; Martin,Knight ^[6] ; Daniela,Loessner ^[7] ; Christopher,Heeschen ^[8] ; Alvaro,Mata ^[9] ; Oliver M T,Pearce ^[4]

作者单位： Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.;School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK. ^[1] School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, NG7 2RD, UK. ^[2] School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK. ^[3] Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK. ^[4] Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, 37134, Italy.;ARC-Net, Applied Research on Cancer Centre, University of Verona, Verona, 37134, Italy. ^[5] Centre for Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.;Centre for Predictive in vitro Models, Queen Mary University of London, London, E1 4NS, UK. ^[6] Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.;Department of Chemical and Biological Engineering, Faculty of Engineering, Monash University, Melbourne, VIC, 3800, Australia.;Department of Materials Science and Engineering, Faculty of Engineering, Monash University, Melbourne, VIC, 3800, Australia.;Department of Anatomy and Developmental Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, 3800, Australia. ^[7] Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute - FPO - IRCCS, Candiolo (TO), 10060, Italy. ^[8] School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.;Biodiscovery Institute, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.;Department of Chemical and Environmental Engineering, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. ^[9]

关键词 3D disease model drug resistance pancreatic cancer peptide amphiphile self‐assembling hydrogels tumor microenvironment tunable stiffness