mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice.

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作者： Nan-Shi-Yu,Yang ^[1] ; Wen-Jing,Zhong ^[2] ; Han-Xi,Sha ^[3] ; Chen-Yu,Zhang ^[1] ; Ling,Jin ^[2] ; Jia-Xi,Duan ^[3] ; Jian-Bing,Xiong ^[1] ; Zhi-Jian,You ^[2] ; Yong,Zhou ^[3] ; Cha-Xiang,Guan ^[1]

作者单位： Department of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China. ^[1] Key Laboratory of General University of Hunan Province, Basic and Clinic Research in Major Respiratory Disease, Changsha, Hunan 410078, China. ^[2] National Experimental Teaching Demonstration Center for Medical Function, Changsha, Hunan 410013, China. ^[3] Department of Anesthesiology, Liuzhou People's Hospital, Liuzhou 545000, China. ^[4]

关键词 NLRP3 inflammasome.cGAS-STING mitochondrial fission neuroinflammation postoperative cognitive dysfunction

主题词小鼠(Mice);动物(Animals);炎性体(Inflammasomes);DNA, 线粒体(DNA, Mitochondrial);核苷酸基转移酶类(Nucleotidyltransferases)

DOI 10.7150/ijbs.91543

PMID 38481801

发布时间 2024-03-15

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