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Formation Pattern Analysis of Spheroids Formed by a Droplet-Based Microfluidic System for Predicting the Aggressiveness of Tumor Cells.

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第一作者： Sunghan,Lee

第一单位： School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seadaemun-gu, Seoul 03722, Republic of Korea.;College of Medicine, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyangsi 10326, Gyeonggi-do, Republic of Korea.

作者： Sunghan,Lee ^[1] ; Chang Jae,Woo ^[2] ; Hyo-Il,Jung ^[3] ; Ki Chang,Nam ^[4] ; Ji Seok,Lim ^[5] ; Bong Seop,Kwak ^[6]

作者单位： School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seadaemun-gu, Seoul 03722, Republic of Korea.;College of Medicine, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyangsi 10326, Gyeonggi-do, Republic of Korea. ^[1] College of Medicine, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyangsi 10326, Gyeonggi-do, Republic of Korea.;National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si 10408, Gyeonggi-do, Republic of Korea. ^[2] School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seadaemun-gu, Seoul 03722, Republic of Korea.;The DABOM Inc., Seodaemun-gu, Seoul 03722, Republic of Korea. ^[3] College of Medicine, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyangsi 10326, Gyeonggi-do, Republic of Korea. ^[4] School of Mechanical Engineering, Yeungnam University, 280 Daehak-ro, Gyeongsan-si 38541, Gyeongsanbuk-do, Republic of Korea.;MediSphere Inc., Gyeongsan-si 38541, Gyeongsanbuk-do, Republic of Korea. ^[5] College of Medicine, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyangsi 10326, Gyeonggi-do, Republic of Korea.;MediSphere Inc., Gyeongsan-si 38541, Gyeongsanbuk-do, Republic of Korea. ^[6]

关键词 aggressive tumor cells cell distribution circularity convexity droplet-based microfluidics system formation patterns spheroid tumor heterogeneity

医学主题词微流体学(Microfluidics);球形体, 细胞(Spheroids, Cellular)

DOI 10.1021/acsbiomaterials.4c00005

PMID 38483467

发布时间 2025-07-30

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