首页> PLoS computational biology> Combining machine learning with structure-based protein design to predict and engineer post-translational modifications of proteins.

Combining machine learning with structure-based protein design to predict and engineer post-translational modifications of proteins.

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第一作者： Moritz,Ertelt

第一单位： Institute for Drug Discovery, Leipzig University Medical Faculty, Leipzig, Germany.;Center for Scalable Data Analytics and Artificial Intelligence ScaDS.AI, Dresden/Leipzig, Germany.

作者： Moritz,Ertelt ^[1] ; Vikram Khipple,Mulligan ^[2] ; Jack B,Maguire ^[3] ; Sergey,Lyskov ^[4] ; Rocco,Moretti ^[5] ; Torben,Schiffner ^[6] ; Jens,Meiler ^[7] ; Clara T,Schoeder ^[1]

作者单位： Institute for Drug Discovery, Leipzig University Medical Faculty, Leipzig, Germany.;Center for Scalable Data Analytics and Artificial Intelligence ScaDS.AI, Dresden/Leipzig, Germany. ^[1] Center for Computational Biology, Flatiron Institute, New York, New York, United States of America. ^[2] Program in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. ^[3] Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America. ^[4] Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America.;Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America. ^[5] Institute for Drug Discovery, Leipzig University Medical Faculty, Leipzig, Germany. ^[6] Institute for Drug Discovery, Leipzig University Medical Faculty, Leipzig, Germany.;Center for Scalable Data Analytics and Artificial Intelligence ScaDS.AI, Dresden/Leipzig, Germany.;Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America.;Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America. ^[7]

主题词蛋白质加工, 转译后(Protein Processing, Post-Translational);蛋白质类(Proteins);磷酰化(Phosphorylation);糖基化(Glycosylation)

DOI 10.1371/journal.pcbi.1011939

PMID 38484014

发布时间 2024-11-09

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