首页> Frontiers in pharmacology> Modification of 4-(4-chlorothiophen-2-yl)thiazol-2-amine derivatives for the treatment of analgesia and inflammation: synthesis and in vitro, in vivo, and in silico studies.

Modification of 4-(4-chlorothiophen-2-yl)thiazol-2-amine derivatives for the treatment of analgesia and inflammation: synthesis and in vitro, in vivo, and in silico studies.

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第一作者： Mater H,Mahnashi

第一单位： Department of Pharmaceutical Chemistry, Pharmacy School, Najran University, Najran, Saudi Arabia.

作者： Mater H,Mahnashi ^[1] ; Umer,Rashid ^[2] ; Hassan Hussain,Almasoudi ^[3] ; Mohammed H,Nahari ^[3] ; Imran,Ahmad ^[4] ; Abdulkarim S,Binshaya ^[5] ; Osama,Abdulaziz ^[6] ; Meshari A,Alsuwat ^[6] ; Muhammad Saeed,Jan ^[7] ; Abdul,Sadiq ^[8]

作者单位： Department of Pharmaceutical Chemistry, Pharmacy School, Najran University, Najran, Saudi Arabia. ^[1] Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan. ^[2] Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia. ^[3] Faculty of Pharmacy, Bahauddin Zakaria University, Multan, Pakistan. ^[4] Department of Medical Laboratory Sciences, College of Applied medical sciences, Prince Sattam bin Abdulaziz University, Alkharj, Saudi Arabia. ^[5] Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Taif University, Al-Taif, Saudi Arabia. ^[6] Department of Pharmacy, Bacha Khan University, Charsadda, Pakistan. ^[7] Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara, Pakistan. ^[8]

关键词 LOX analgesic cyclooxygenase in vivo mechanism inflammation thiazole

DOI 10.3389/fphar.2024.1366695

PMID 38487174

发布时间 2024-03-16

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