首页> Journal of enzyme inhibition and medicinal chemistry> New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies.

New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies.

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第一作者： Asmaa H,Mohamed

第一单位： Chemistry Department, Faculty of Science, Minia University, El-Minia, Egypt.

作者： Asmaa H,Mohamed ^[1] ; Mohammed B,Alshammari ^[2] ; Ashraf A,Aly ^[1] ; Kamal U,Sadek ^[1] ; Akil,Ahmad ^[2] ; Eman A,Aziz ^[1] ; Amira F,El-Yazbi ^[3] ; Eman J,El-Agroudy ^[4] ; Marwa E,Abdelaziz ^[4]

作者单位： Chemistry Department, Faculty of Science, Minia University, El-Minia, Egypt. ^[1] Chemistry Department, College of Sciences and Humanities, Prince Sattam Bin Abdulaziz University, Al-Kharij, Saudi Arabia. ^[2] Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt. ^[3] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt. ^[4]

关键词 DNA intercalators New imidazole-2-thiones doxorubicin dual anticancer activity topoisomerase II inhibitor