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Translational genetics identifies a phosphorylation switch in CARD9 required for innate inflammatory responses.

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第一作者： Marta,Brandt

第一单位： Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

作者： Marta,Brandt ^[1] ; Zhifang,Cao ^[2] ; Chirag,Krishna ^[3] ; Jennifer L,Reedy ^[4] ; Xiebin,Gu ^[5] ; Richard A,Dutko ^[4] ; Blayne A,Oliver ^[5] ; Betsabeh Khoramian,Tusi ^[2] ; Jihye,Park ^[1] ; Lauren,Richey ^[6] ; Åsa,Segerstolpe ^[1] ; Scott,Litwiler ^[7] ; Elizabeth A,Creasey ^[5] ; Kimberly L,Carey ^[1] ; Jatin M,Vyas ^[4] ; Daniel B,Graham ^[2] ; Ramnik J,Xavier ^[8]

作者单位： Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. ^[1] Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. ^[2] Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. ^[3] Division of Infectious Disease, Massachusetts General Hospital, Boston, MA 02114, USA. ^[4] Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. ^[5] Tufts Comparative Medicine Services, Tufts University, Boston, MA 02111, USA. ^[6] Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. ^[7] Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: rxavier@broadinstitute.org. ^[8]

关键词 CARD9 CP: Immunology PKCδ antifungal immune response cytokine signaling dermatophytosis