首页> Molecular cell> Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency.

Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency.

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第一作者： David,Lando

第一单位： Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.

作者： David,Lando ^[1] ; Xiaoyan,Ma ^[1] ; Yang,Cao ^[1] ; Aleksandra,Jartseva ^[1] ; Tim J,Stevens ^[2] ; Wayne,Boucher ^[1] ; Nicola,Reynolds ^[3] ; Bertille,Montibus ^[3] ; Dominic,Hall ^[4] ; Andreas,Lackner ^[5] ; Ramy,Ragheb ^[3] ; Martin,Leeb ^[5] ; Brian D,Hendrich ^[6] ; Ernest D,Laue ^[7]

作者单位： Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK. ^[1] MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. ^[2] Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge CB2 0AW, UK. ^[3] Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge CB2 0AW, UK. ^[4] Max Perutz Laboratories Vienna, University of Vienna, Vienna Biocenter, Vienna, Austria. ^[5] Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge CB2 0AW, UK. Electronic address: bdh24@cam.ac.uk. ^[6] Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge CB2 0AW, UK. Electronic address: e.d.laue@bioc.cam.ac.uk. ^[7]

关键词 3D genome structure ES cells H3K27 methylation Hi-C experiments PRC1/2 complexes chromosome intermingling formative state multiway hubs pluripotency exit single cells transcriptional bursting

医学主题词小鼠(Mice);动物(Animals);调控序列, 核酸(Regulatory Sequences, Nucleic Acid);胚胎干细胞(Embryonic Stem Cells);转录因子(Transcription Factors);染色质(Chromatin);增强子元件, 遗传学(Enhancer Elements, Genetic)

DOI 10.1016/j.molcel.2024.02.015

PMID 38490199

发布时间 2025-05-30

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