Preparation, Characterization and In vitro Evaluation of Insulin-PHBV Nanoparticles/Alginate Hydrogel Composite System for Prolonged Delivery of Insulin.

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作者： Samane,Bayrami ^[1] ; Mehdi,Chamani ^[1] ; SaeidReza,JamaliMoghadamSiahkali ^[2] ; SeyedAhmad,SeyedAlinaghi ^[3] ; Leila Rezaie,Shirmard ^[4] ; Sepide,Bayrami ^[5] ; Hamid Akbari,Javar ^[1] ; Mohammad Hossein,Ghahremani ^[6] ; Mohsen,Amini ^[7] ; Morteza Rafiee,Tehrani ^[1] ; Shadab,Shahsavari ^[8] ; Farid Abedin,Dorkoosh ^[9]

作者单位： Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. ^[1] Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran. ^[2] Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran. ^[3] Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran. ^[4] Islamic Azad University, North Tehran Branch, Faculty of Bioscience, Tehran, Iran. ^[5] Department of Toxicology-Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. ^[6] Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran. ^[7] Chemical Engineering Department, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran. ^[8] Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Medical Biomaterial Research Centre (MBRC), Tehran University of Medical Sciences, Tehran 14399-56131, Iran. Electronic address: dorkoosh@tums.ac.ir. ^[9]

关键词 Biocompatibility Biodegradable polymer Cell line Composite hydrogel Controlled release Drug delivery system Insulin PHBV nanoparticles Prolonged delivery Sodium alginate/jeffamine hydrogel