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A fungal P450 enzyme from Fusarium equiseti HG18 with 7β-hydroxylase activity in biosynthesis of ursodeoxycholic acid.

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第一作者： Zhen-Ru,Zhou

第一单位： MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.

作者： Zhen-Ru,Zhou ^[1] ; Fen,Liu ^[1] ; Shan,Li ^[1] ; Chang-Zhi,Dong ^[2] ; Lei,Zhang ^[3]

作者单位： MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China. ^[1] Université Paris Cité, Sorbonne Paris Cité, ITODYS, UMR 7086 CNRS, 15 rue J-A de Baïf, Cedex 13, Paris 75205, France. ^[2] MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China; NMPA Key Laboratory for Quality Control of Blood Products, South China University of Technology, Guangzhou, China. Electronic address: lzhangce@scut.edu.cn. ^[3]

关键词 7β-Hydroxylase Fusarium equiseti HG18 Lithocholic acid Ursodeoxycholic acid