Beyond Conventional Therapies: Molecular Dynamics of Alzheimer's Treatment through CLOCK/BMAL1 Interactions.

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作者： Ismail Celil,Haskologlu ^[1] ; Emine,Erdag ^[2] ; Ahmet Ozer,Sehirli ^[3] ; Orhan,Uludag ^[4] ; Nurettin,Abacioglu ^[1]

作者单位： Department of Pharmacology, Faculty of Pharmacy, Near East University, Nicosia Mersin-10, Near East Boulevard 99138, Türkiye. ^[1] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Near East University, Nicosia Mersin- 10, Near East Boulevard 99138, Türkiye. ^[2] Department of Pharmacology, Faculty of Dentistry, Near East University, Nicosia Mersin-10, Near East Boulevard 99138, Türkiye. ^[3] Department of Clinical Pharmacy, Faculty of Pharmacy, Near East University, Nicosia Mersin-10, Near East Boulevard 99138, Türkiye. ^[4]

关键词 Alzheimer's disease.Bmal1 FDA-approved drugs chronotherapy melatonin molecular docking

主题词阿尔茨海默病(Alzheimer Disease);人类(Humans);ARNTL转录因子类(ARNTL Transcription Factors);褪黑激素(Melatonin);时钟蛋白质类(CLOCK Proteins);分子动力学模拟(Molecular Dynamics Simulation);胆碱酯酶抑制剂(Cholinesterase Inhibitors)

DOI 10.2174/0115672050301014240315065235

PMID 38509675

发布时间 2024-08-12

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