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    首页> Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie> "Keep on ROCKIn": Repurposed ROCK inhibitors to boost corneal endothelial regeneration.

    "Keep on ROCKIn": Repurposed ROCK inhibitors to boost corneal endothelial regeneration.

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    第一作者： Hendrik,Vercammen
    第一单位： Antwerp Research Group for Ocular Science (ARGOS), Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium; Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium; DrugVision Lab, University of Antwerp, Wilrijk, Belgium. Electronic address: hendrik.vercammen@uantwerpen.be.
    作者： Hendrik,Vercammen [1] ; Martin,Ondra [2] ; Jana,Kotulova [3] ; Edgar Cardenas,De La Hoz [4] ; Charissa,Witters [5] ; Katerina,Jecmenova [3] ; Maxim,Le Compte [6] ; Christophe,Deben [6] ; Sorcha,Ní Dhubhghaill [7] ; Carina,Koppen [8] ; Marián,Hajdúch [2] ; Bert,Van den Bogerd [9]
    作者单位： Antwerp Research Group for Ocular Science (ARGOS), Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium; Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium; DrugVision Lab, University of Antwerp, Wilrijk, Belgium. Electronic address: hendrik.vercammen@uantwerpen.be. [1] Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic; Czech Advanced Technology and Research Institute (CATRIN), Palacky University Olomouc, Olomouc, Czech Republic. [2] Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic. [3] Industrial Vision Lab, University of Antwerp, Wilrijk, Belgium. [4] Antwerp Research Group for Ocular Science (ARGOS), Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium; Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium; DrugVision Lab, University of Antwerp, Wilrijk, Belgium. [5] DrugVision Lab, University of Antwerp, Wilrijk, Belgium. [6] Department of Ophthalmology, Brussels University Hospital, Jette, Belgium. [7] Antwerp Research Group for Ocular Science (ARGOS), Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium; Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium. [8] Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic; Czech Advanced Technology and Research Institute (CATRIN), Palacky University Olomouc, Olomouc, Czech Republic. Electronic address: Bert.VandenBogerd@uantwerpen.be. [9]
    关键词 Chroman-1Corneal endothelial regenerationDrug repurposingROCK inhibitorsSmall molecule screening
    主题词 rho相关激酶类(rho-Associated Kinases);细胞增殖(Cell Proliferation);蛋白激酶抑制剂(Protein Kinase Inhibitors);内皮, 角膜(Endothelium, Corneal);再生(Regeneration);动物(Animals);药物重新定位(Drug Repositioning);细胞运动(Cell Movement);细胞系(Cell Line);人类(Humans);内皮细胞(Endothelial Cells)
    DOI 10.1016/j.biopha.2024.116435
    PMID 38513591
    发布时间 2024-04-30
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