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Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.

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第一作者： Wei,Yang

第一单位： Department of Ophthalmology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan , China.

作者： Wei,Yang ^[1] ; Chen,Qiu ^[1] ; Hongbin,Lv ^[1] ; Zhiru,Zhang ^[2] ; Tianyu,Yao ^[3] ; Li,Huang ^[4] ; Guihong,Wu ^[1] ; Xueqin,Zhang ^[1] ; Jie,Chen ^[5] ; Yue,He ^[6]

作者单位： Department of Ophthalmology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan , China. ^[1] Department of Ophthalmology, People's Hospital of Deyang City, Deyang, Sichuan, China. ^[2] Department of Ophthalmology, The Second People's Hospital of Yibin, Yibin, Sichuan, China. ^[3] Sichuan Vocational College of Health and Rehabilitation, Zigong, Sichuan, China. ^[4] Department of Rheumatology and Immunology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. ^[5] Department of Ophthalmology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan , China.;Stem Cell Immunity and Regeneration Key Laboratory of Luzhou, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China. ^[6]

医学主题词 AMP活化蛋白激酶类(AMP-Activated Protein Kinases);糖尿病视网膜病变(Diabetic Retinopathy);上皮细胞(Epithelial Cells);葡萄糖(Glucose);活性氧(Reactive Oxygen Species);视网膜(Retina);抗衰老酶3(Sirtuin 3);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);人类(Humans)

DOI 10.1167/tvst.13.3.19

PMID 38517447

发布时间 2025-08-22

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Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.

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Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.

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