C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire.

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作者： Ivan,Kosik ^[1] ; Jefferson,Da Silva Santos ^[1] ; Mathew,Angel ^[1] ; Zhe,Hu ^[1] ; Jaroslav,Holly ^[1] ; James S,Gibbs ^[1] ; Tanner,Gill ^[1] ; Martina,Kosikova ^[2] ; Tiansheng,Li ^[1] ; William,Bakhache ^[3] ; Patrick T,Dolan ^[3] ; Hang,Xie ^[2] ; Sarah F,Andrews ^[4] ; Rebecca A,Gillespie ^[5] ; Masaru,Kanekiyo ^[5] ; Adrian B,McDermott ^[4] ; Theodore C,Pierson ^[6] ; Jonathan W,Yewdell ^[1]

作者单位： Cellular Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. ^[1] Laboratory of Respiratory Viral Diseases, Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. ^[2] Quantitative Virology and Evolution Unit, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. ^[3] Vaccine Immunology Program, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. ^[4] Molecular Immunoengineering Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. ^[5] Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. ^[6]

主题词小鼠(Mice);动物(Animals);人类(Humans);血凝素类(Hemagglutinins);流感, 人(Influenza, Human);补体C1q(Complement C1q);病毒吸附(Virus Attachment);血凝素糖蛋白类, 流感病毒(Hemagglutinin Glycoproteins, Influenza Virus);抗体, 病毒(Antibodies, Viral);流感疫苗(Influenza Vaccines)

DOI 10.1126/sciimmunol.adj9534

PMID 38517951

发布时间 2024-04-02

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Science immunology

2024年9卷93期

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C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire.

Science immunology

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C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire.

Science immunology

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Science immunology

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