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High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant A. baumannii and K. pneumoniae.

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第一作者： Benjamin,Blasco

第一单位： Global Antibiotic Research and Development Partnership (GARDP), 15 Chemin Camille-Vidart, 1202, Geneva, Switzerland.

作者： Benjamin,Blasco ^[1] ; Soojin,Jang ^[2] ; Hiroki,Terauchi ^[3] ; Naoki,Kobayashi ^[3] ; Shuichi,Suzuki ^[3] ; Yuichiro,Akao ^[4] ; Atsuko,Ochida ^[4] ; Nao,Morishita ^[4] ; Terufumi,Takagi ^[4] ; Hiroyuki,Nagamiya ^[4] ; Yamato,Suzuki ^[5] ; Toshiaki,Watanabe ^[5] ; Hyunjung,Lee ^[2] ; Sol,Lee ^[2] ; David,Shum ^[2] ; Ahreum,Cho ^[2] ; Dahae,Koh ^[2] ; Soonju,Park ^[2] ; Honggun,Lee ^[2] ; Kideok,Kim ^[2] ; Henni-Karoliina,Ropponen ^[1] ; Renata Maria,Augusto da Costa ^[1] ; Steven,Dunn ^[6] ; Sunil,Ghosh ^[7] ; Peter,Sjö ^[8] ; Laura J V,Piddock ^[9]

作者单位： Global Antibiotic Research and Development Partnership (GARDP), 15 Chemin Camille-Vidart, 1202, Geneva, Switzerland. ^[1] Institut Pasteur Korea, 16, Daewangpangyo-ro 712 beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, South Korea. ^[2] Eisai Co., Ltd., Tsukuba Research Laboratories, 5-1-3 Tokodai, Tsukuba, Ibaraki, 300-2635, Japan. ^[3] Takeda Pharmaceutical Company Ltd, 261, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan. ^[4] Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan. ^[5] Dunn Genomics, United Kingdom. ^[6] TCG Lifesciences Private Limited, Block BN, Plot 7, Salt Lake Electronics Complex, Sector V, Kolkata, 700091, West Bengal, India. ^[7] Drugs for Neglected Diseases Initiative, 15 Chemin Camille-Vidart, 1202, Geneva, Switzerland. ^[8] Global Antibiotic Research and Development Partnership (GARDP), 15 Chemin Camille-Vidart, 1202, Geneva, Switzerland. Electronic address: lpiddock@gardp.org. ^[9]

关键词 Acinetobacter baumannii Antibacterial drug discovery High-throughput screening Klebsiella pneumoniae Multidrug-resistance

医学主题词人类(Humans);高通量筛选分析(High-Throughput Screening Assays);小分子化合物库(Small Molecule Libraries);肺炎克雷伯菌(Klebsiella pneumoniae);微生物敏感性试验(Microbial Sensitivity Tests);抗菌药(Anti-Bacterial Agents);大肠杆菌(Escherichia coli);抗药性, 多种, 细菌(Drug Resistance, Multiple, Bacterial)

DOI 10.1016/j.ebiom.2024.105073

PMID 38520916

发布时间 2024-11-09

基金项目

WT_/Wellcome Trust/United Kingdom

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High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant A. baumannii and K. pneumoniae.

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High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant A. baumannii and K. pneumoniae.

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