Integrative multi-omics analysis identifies genetically supported druggable targets and immune cell specificity for myasthenia gravis.

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第一作者： Jiao,Li

第一单位： Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, 100053, China.;Beijing Municipal Geriatric Medical Research Center, Beijing, China.;Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, China.

作者： Jiao,Li ^[1] ; Fei,Wang ^[2] ; Zhen,Li ^[3] ; Jingjing,Feng ^[3] ; Yi,Men ^[3] ; Jinming,Han ^[3] ; Jiangwei,Xia ^[3] ; Chen,Zhang ^[3] ; Yilai,Han ^[3] ; Teng,Chen ^[3] ; Yinan,Zhao ^[3] ; Sirui,Zhou ^[4] ; Yuwei,Da ^[3] ; Guoliang,Chai ^[5] ; Junwei,Hao ^[6]

作者单位： Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, 100053, China.;Beijing Municipal Geriatric Medical Research Center, Beijing, China.;Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, China. ^[1] Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, 100053, China.;Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, China. ^[2] Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, 100053, China. ^[3] Department of Human Genetics, McGill University, Montréal, QC, Canada. ^[4] Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, 100053, China. guoliang.chai@xwh.ccmu.edu.cn.;Beijing Municipal Geriatric Medical Research Center, Beijing, China. guoliang.chai@xwh.ccmu.edu.cn. ^[5] Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, 100053, China. haojunwei@vip.163.com.;Beijing Municipal Geriatric Medical Research Center, Beijing, China. haojunwei@vip.163.com.;Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, China. haojunwei@vip.163.com. ^[6]

关键词 Actionable druggable genome Cell-type specificity Genetic colocalization Mendelian randomization Myasthenia gravis

主题词人类(Humans);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);重症肌无力(Myasthenia Gravis);数量性状基因座位(Quantitative Trait Loci);多态性, 单核苷酸(Polymorphism, Single Nucleotide)

DOI 10.1186/s12967-024-04994-2

PMID 38521921

发布时间 2024-08-07

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