Developing Dynamic Structure-Based Pharmacophore and ML-Trained QSAR Models for the Discovery of Novel Resistance-Free RET Tyrosine Kinase Inhibitors Through Extensive MD Trajectories and NRI Analysis.
作者:
主题词
原癌基因蛋白质c-ret(Proto-Oncogene Proteins c-ret);蛋白激酶抑制剂(Protein Kinase Inhibitors);人类(Humans);量化构效关系(Quantitative Structure-Activity Relationship);分子动力学模拟(Molecular Dynamics Simulation);分子结构(Molecular Structure);药物发现(Drug Discovery);小分子化合物库(Small Molecule Libraries)
DOI
10.1002/cmdc.202300644
PMID
38523069
发布时间
2024-06-18
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ChemMedChem
e202300644页
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