An oocyte-specific Cas9-expressing mouse for germline CRISPR/Cas9-mediated genome editing.

导出 OA

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作者： Denise G,Lanza ^[1] ; Jianqiang,Mao ^[2] ; Isabel,Lorenzo ^[1] ; Lan,Liao ^[2] ; John R,Seavitt ^[1] ; M Cecilia,Ljungberg ^[3] ; Elizabeth M,Simpson ^[4] ; Francesco J,DeMayo ^[5] ; Jason D,Heaney ^[6]

作者单位： Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA. ^[1] Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, Texas, USA. ^[2] Department of Pediatrics - Neurology, Baylor College of Medicine, Houston, Texas, USA. ^[3] Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas, USA. ^[4] Centre for Molecular Medicine and Therapeutics at BC Children's Hospital, Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada. ^[5] Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. ^[6] Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA. ^[7]

关键词 CRISPR SpCas9 genome editing germline mutations