Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity.

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作者： Linyuan,Peng ^[1] ; Liang,Zhou ^[2] ; Huan,Li ^[2] ; Xin,Zhang ^[1] ; Su,Li ^[1] ; Kai,Wang ^[1] ; Mei,Yang ^[1] ; Xiaoyu,Ma ^[1] ; Danlan,Zhang ^[2] ; Siliang,Xiang ^[1] ; Yajun,Duan ^[1] ; Tianzhi,Wang ^[1] ; Chunmeng,Sun ^[3] ; Chen,Wang ^[1] ; Desheng,Lu ^[4] ; Minxian,Qian ^[5] ; Zhongyuan,Wang ^[6]

作者单位： State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China. ^[1] Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Cancer Research Center, Department of Pharmacology, Shenzhen University Medical School, Shenzhen 518055, China. ^[2] State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China. ^[3] Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Cancer Research Center, Department of Pharmacology, Shenzhen University Medical School, Shenzhen 518055, China. Electronic address: delu@szu.edu.cn. ^[4] State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China. Electronic address: qmx@cpu.edu.cn. ^[5] State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China. Electronic address: wangzhongyuan@cpu.edu.cn. ^[6]

关键词 CP: Cancer CP: Immunology Hippo pathway MHC class I NLRC5 NuRD complex TAZ TEAD YAP antigen processing and presentation antitumor immunity immune checkpoint blockade