Cyclin dependent kinase 4/6 inhibitor palbociclib synergizes with BCL2 inhibitor venetoclax in experimental models of mantle cell lymphoma without RB1 deletion.

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第一作者： Diana,Malarikova

第一单位： Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.

作者： Diana,Malarikova ^[1] ; Radek,Jorda ^[2] ; Kristyna,Kupcova ^[3] ; Jana,Senavova ^[2] ; Alexandra,Dolnikova ^[4] ; Eva,Pokorna ^[2] ; Dmitry,Kazantsev ^[4] ; Kristina,Nozickova ^[1] ; Dana,Sovilj ^[1] ; Celine,Bellanger ^[1] ; David,Chiron ^[1] ; Ladislav,Andera ^[5] ; Vladimir,Krystof ^[6] ; Miroslav,Strnad ^[6] ; Karel,Helman ^[4] ; Magdalena,Klanova ^[5] ; Marek,Trneny ^[7] ; Ondrej,Havranek ^[3] ; Pavel,Klener ^[8]

作者单位： Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic. ^[1] First Department of Internal Medicine - Hematology, First Faculty of Medicine, General University Hospital, Charles University, Prague, Czech Republic. ^[2] Department of Experimental Biology, Faculty of Science, Palacky University Olomouc, Olomouc, Czech Republic. ^[3] BIOCEV LF1 - Biotechnology and Biomedicine Centre, First Faculty of Medicine, Charles University, Prague, Czech Republic. ^[4] Institute of Biotechnology, Czech Academy of Sciences, Prague, Czech Republic. ^[5] Integrated Research Center in Immunology and Oncology, CRCI2NA, Nantes University, Nantes, France. ^[6] Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic. ^[7] Laboratory of Growth Regulators, Palacky University Olomouc and Institute of Experimental Botany, The Czech Academy of Sciences, Olomouc, Czech Republic. ^[8] Faculty of Informatics and Statistics, Prague University of Economics and Business, Prague, Czech Republic. ^[9] Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic. pavel.klener2@lf1.cuni.cz. ^[10] First Department of Internal Medicine - Hematology, First Faculty of Medicine, General University Hospital, Charles University, Prague, Czech Republic. pavel.klener2@lf1.cuni.cz. ^[11]

关键词 BCL2 Cyclin-dependent kinase (CDK) inhibitors Mantle cell lymphoma (MCL)Palbociclib RB1 Venetoclax

DOI 10.1186/s40164-024-00499-2

PMID 38528594

发布时间 2024-03-28

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