Head and neck cancer of unknown primary: unveiling primary tumor sites through machine learning on DNA methylation profiles.

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第一作者： Leonhard,Stark

第一单位： Department of Otolaryngology, Head and Neck Surgery, School of Medicine and Health, Technical University of Munich, Munich, Germany. leo.stark@tum.de.

作者： Leonhard,Stark ^[1] ; Atsuko,Kasajima ^[2] ; Fabian,Stögbauer ^[3] ; Benedikt,Schmidl ^[3] ; Jakob,Rinecker ^[4] ; Katharina,Holzmann ^[4] ; Sarah,Färber ^[4] ; Nicole,Pfarr ^[4] ; Katja,Steiger ^[3] ; Barbara,Wollenberg ^[3] ; Jürgen,Ruland ^[4] ; Christof,Winter ^[5] ; Markus,Wirth ^[6]

作者单位： Department of Otolaryngology, Head and Neck Surgery, School of Medicine and Health, Technical University of Munich, Munich, Germany. leo.stark@tum.de. ^[1] Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Technical University of Munich, Munich, Germany. leo.stark@tum.de. ^[2] Institute of Pathology, School of Medicine and Health, Technical University of Munich, Munich, Germany. ^[3] Department of Otolaryngology, Head and Neck Surgery, School of Medicine and Health, Technical University of Munich, Munich, Germany. ^[4] Partner Site Munich and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany. ^[5] Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine and Health, Technical University of Munich, Munich, Germany. ^[6] Center for Translational Cancer Research, TranslaTUM, Technical University of Munich, Munich, Germany. ^[7]

关键词 CUP Classifier DNA methylation HNSCC

主题词人类(Humans);DNA甲基化(DNA Methylation);肿瘤, 未知原发灶(Neoplasms, Unknown Primary);头颈部肿瘤(Head and Neck Neoplasms);癌, 鳞状细胞(Carcinoma, Squamous Cell)

DOI 10.1186/s13148-024-01657-3

PMID 38528631

发布时间 2024-04-05

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