Association between genetic risk and adherence to healthy lifestyle for developing age-related hearing loss.

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第一作者： Sang-Hyuk,Jung

第一单位： Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

作者： Sang-Hyuk,Jung ^[1] ; Young Chan,Lee ^[2] ; Manu,Shivakumar ^[1] ; Jaeyoung,Kim ^[3] ; Jae-Seung,Yun ^[4] ; Woong-Yang,Park ^[5] ; Hong-Hee,Won ^[6] ; Penn Medicine Biobank ^[7] ; Dokyoon,Kim

作者单位： Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[1] Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea. ^[2] Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea. ^[3] Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. ^[4] Samsung Genome Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. ^[5] Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea.;Samsung Genome Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. ^[6] Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. dokyoon.kim@pennmedicine.upenn.edu.;Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, USA. dokyoon.kim@pennmedicine.upenn.edu. ^[7]

关键词 Age-related hearing loss Environmental factor Genetic risk Lifestyle Polygenic risk score

主题词人类(Humans);病例对照研究(Case-Control Studies);全基因组关联研究(Genome-Wide Association Study);危险因素(Risk Factors);老年性聋(Presbycusis);疾病遗传易感性(Genetic Predisposition to Disease)

DOI 10.1186/s12916-024-03364-5

PMID 38532472

发布时间 2024-11-16

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