Mechanistic studies to understand peak tailing due to sulfinic acid- and carboxylic acid-silanophilic interactions in reversed-phase liquid chromatography.

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第一作者： Yiyang,Zhou

第一单位： Chemical Process Development, Bristol Myers Squibb Company, 1 Squibb Drive, New Brunswick, NJ 08903, USA. Electronic address: yiyang.zhou@bms.com.

作者： Yiyang,Zhou ^[1] ; Antonio,Ramirez ^[2] ; Elizabeth M,Yuill ^[2] ; Qinggang,Wang ^[2]

作者单位： Chemical Process Development, Bristol Myers Squibb Company, 1 Squibb Drive, New Brunswick, NJ 08903, USA. Electronic address: yiyang.zhou@bms.com. ^[1] Chemical Process Development, Bristol Myers Squibb Company, 1 Squibb Drive, New Brunswick, NJ 08903, USA. ^[2]

关键词 Density functional theory calculations Hydrophobic subtraction model Organic acids Peak tailing Reversed-phase liquid chromatography Silanol

主题词色谱法, 反相(Chromatography, Reverse-Phase);亚磺酸类(Sulfinic Acids);羧酸类(Carboxylic Acids);指示剂和试剂(Indicators and Reagents);醋酸(Acetic Acid);色谱法, 高压液相(Chromatography, High Pressure Liquid)

DOI 10.1016/j.chroma.2024.464819

PMID 38537485

发布时间 2024-05-08

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