The pain target Na<sub>V</sub>1.7 is expressed late during human iPS cell differentiation into sensory neurons as determined in high-resolution imaging.

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作者： Yi,Liu ^[1] ; Rachna,Balaji ^[1] ; Marcelo A Szymanski,de Toledo ^[2] ; Sabrina,Ernst ^[3] ; Petra,Hautvast ^[1] ; Aylin B,Kesdoğan ^[1] ; Jannis,Körner ^[1] ; Martin,Zenke ^[4] ; Anika,Neureiter ^[5] ; Angelika,Lampert ^[6]

作者单位： Institute of Neurophysiology, Uniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. ^[1] Department of Hematology, Oncology, and Stem Cell Transplantation, Uniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. ^[2] Confocal Microscopy Facility, Interdisciplinary Center for Clinical Research IZKF, Uniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. ^[3] Department of Anaesthesiology, Uniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. ^[4] Department of Intensive and Intermediate Care, Uniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. ^[5] Scientific Center for Neuropathic Pain Research Aachen, SCN-Aachen Uniklinik RWTH Aachen, Aachen, Germany. ^[6] Institute of Neurophysiology, Uniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. aneureiter@ukaachen.de. ^[7] Institute of Neurophysiology, Uniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. alampert@ukaachen.de. ^[8] Scientific Center for Neuropathic Pain Research Aachen, SCN-Aachen Uniklinik RWTH Aachen, Aachen, Germany. alampert@ukaachen.de. ^[9]

关键词 CRISPR-Cas Disease modeling HA-tag Membrane localization Stem cell–derived sensory neurons

主题词诱导多能干细胞(Induced Pluripotent Stem Cells);人类(Humans);感觉感受器细胞(Sensory Receptor Cells);细胞分化(Cell Differentiation);动作电位(Action Potentials)

DOI 10.1007/s00424-024-02945-w

PMID 38538988

发布时间 2024-06-03

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