Upregulation of Notch Signaling and Cell-Differentiation Inhibitory Transcription Factors in Stable Chronic Obstructive Pulmonary Disease Patients.

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作者： Antonino,Di Stefano ^[1] ; Isabella,Gnemmi ^[1] ; Umberto,Rosani ^[2] ; Mauro,Maniscalco ^[3] ; Silvestro Ennio,D'Anna ^[3] ; Paola,Brun ^[4] ; Vitina,Carriero ^[5] ; Francesca,Bertolini ^[5] ; Bruno,Balbi ^[1] ; Fabio Luigi Massimo,Ricciardolo ^[6]

作者单位： Divisione di Pneumologia, Laboratorio di Citoimmunopatologia dell'Apparato Cardio Respiratorio, Istituti Clinici Scientifici Maugeri, IRCCS, Respiratory Rehabilitation Unit of Gattico-Veruno, 28013 Gattico-Veruno, Italy. ^[1] Department of Biology, University of Padova, via U. Bassi 58/b, 35121 Padova, Italy. ^[2] Divisione di Pneumologia, Istituti Clinici Scientifici Maugeri, IRCCS, 82037 Telese Terme, Italy. ^[3] Department of Molecular Medicine, Histology Unit, University of Padova, 35121 Padova, Italy. ^[4] Department of Clinical and Biological Sciences, Severe Asthma and Rare Lung Disease Unit, San Luigi Gonzaga University Hospital, University of Turin, 10043 Orbassano, Italy. ^[5] Azienda Sanitaria Locale (ASL), 28100 Novara, Italy. ^[6]

关键词 Notch signaling airway inflammation bronchiolar epithelial cells endothelial cells pulmonary rehabilitation stem cells

主题词人类(Humans);转录因子(Transcription Factors);增量调节(Up-Regulation);肺疾病, 慢性阻塞性(Pulmonary Disease, Chronic Obstructive);受体, Notch(Receptors, Notch);细胞分化(Cell Differentiation);受体, Notch1(Receptor, Notch1)

DOI 10.3390/ijms25063287

PMID 38542260

发布时间 2024-03-30

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