Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease.

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作者： Yuan,Li ^[1] ; Tingting,Xu ^[2] ; Yue,Zhao ^[2] ; Hui,Zhang ^[2] ; Zesheng,Liu ^[2] ; Hao,Wang ^[1] ; Chaoying,Huang ^[3] ; Zhihao,Shu ^[1] ; Lixin,Gao ^[1] ; Rongrong,Xie ^[1] ; Tingying,Jiao ^[1] ; Dan,Zhang ^[1] ; Dong,Zhang ^[1] ; Xuewu,Liang ^[1] ; Yi,Zang ^[4] ; Yili,Sun ^[1] ; Hong,Liu ^[5] ; Jia,Li ^[1] ; Yu,Zhou ^[2]

作者单位： Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. ^[1] School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. ^[2] School of Medicine, Shanghai University, Shanghai, 200444, China. ^[3] Lingang laboratory, Shanghai, 201203, China. ^[4] Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China. ^[5] School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China. ^[6]

DOI 10.1021/acs.jmedchem.3c02304

PMID 38547240

发布时间 2024-04-11

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Journal of medicinal chemistry

2024年67卷7期

5642-5661页

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Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease.

Journal of medicinal chemistry

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Journal of medicinal chemistry

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Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease.

Journal of medicinal chemistry

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Journal of medicinal chemistry

相关期刊

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