Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs-a proof-of-concept study with doxorubicin.

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第一作者： Li,Pang

第一单位： Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA.

作者： Li,Pang ^[1] ; Chengzhong,Cai ^[1] ; Praful,Aggarwal ^[2] ; Dong,Wang ^[3] ; Vikrant,Vijay ^[1] ; Prathyusha,Bagam ^[1] ; Jacob,Blamer ^[2] ; Andrea,Matter ^[2] ; Amy,Turner ^[2] ; Lijun,Ren ^[1] ; Katy,Papineau ^[1] ; Vinodh,Srinivasasainagendra ^[4] ; Hemant K,Tiwari ^[4] ; Xi,Yang ^[5] ; Laura,Schnackenberg ^[1] ; William,Mattes ^[1] ; Ulrich,Broeckel ^[2]

作者单位： Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. ^[1] Department of Pediatrics, Section of Genomic Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. ^[2] Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. ^[3] Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. ^[4] Division of Pharmacology & Toxicology, Office of Cardiology, Hematology, Endocrinology, & Nephrology, Office of New Drug, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20903, USA. ^[5]

关键词 in vitro cytotoxicity doxorubicin-induced cardiotoxicity (DIC)induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs)interindividual variability transcriptome profiling

主题词多柔比星(Doxorubicin);诱导多能干细胞(Induced Pluripotent Stem Cells);人类(Humans);肌细胞, 心脏(Myocytes, Cardiac);抗生素类, 抗肿瘤(Antibiotics, Antineoplastic);剂量效应关系, 药物(Dose-Response Relationship, Drug);抗肿瘤药(Antineoplastic Agents)

DOI 10.1093/toxsci/kfae041

PMID 38547396

发布时间 2024-06-28

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