Decellularized Brain Extracellular Matrix Hydrogel Aids the Formation of Human Spinal-Cord Organoids Recapitulating the Complex Three-Dimensional Organization.

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作者： Weidong,Wu ^[1] ; Youjun,Liu ^[2] ; Renfeng,Liu ^[3] ; Yuhao,Wang ^[2] ; Yuqi,Zhao ^[3] ; Hui,Li ^[2] ; Botao,Lu ^[3] ; Cheng,Ju ^[2] ; Xinlin,Gao ^[3] ; Hailiang,Xu ^[2] ; Yulin,Cao ^[3] ; Shixiang,Cheng ^[2] ; Zhiyuan,Wang ^[3] ; Shuaijun,Jia ^[2] ; Chunping,Hu ^[3] ; Lei,Zhu ^[2] ; Dingjun,Hao ^[3]

作者单位： Department of Orthopedics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. ^[1] Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Youyi East Road No. 555, Beilin District, Xi'an, Shaanxi, China 710001. ^[2] Shaanxi Key Laboratory of Spine Bionic Treatment, Youyi East Road No. 555, Beilin District, Xi'an, Shaanxi, China 710001. ^[3] Healthina Academy of Cellular Intelligence Manufacturing & Neurotrauma Repair of Tianjin Economic-Technological Development Area, No. 220 DongTing Road, TEDA District, Tianjin 300457, China. ^[4] TANGYI Biomedicine (Tianjin) Co., Ltd. (TBMed), No. 286 Anshan West Road, Nankai District, Tianjin 300190, China. ^[5]

关键词 decellularized brain extracellular matrix hydrogels spinal cord organoids

主题词类器官(Organoids);人类(Humans);动物(Animals);脊髓(Spinal Cord);诱导多能干细胞(Induced Pluripotent Stem Cells);水凝胶类(Hydrogels);脑(Brain);大鼠(Rats);细胞外基质(Extracellular Matrix);层黏连蛋白(Laminin);蛋白聚糖类(Proteoglycans);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);复方合剂(Drug Combinations);胶原(Collagen)

DOI 10.1021/acsbiomaterials.4c00029

PMID 38557027

发布时间 2024-06-12

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ACS biomaterials science & engineering

2024年10卷5期

3203-3217页

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Decellularized Brain Extracellular Matrix Hydrogel Aids the Formation of Human Spinal-Cord Organoids Recapitulating the Complex Three-Dimensional Organization.

ACS biomaterials science & engineering

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ACS biomaterials science & engineering

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Decellularized Brain Extracellular Matrix Hydrogel Aids the Formation of Human Spinal-Cord Organoids Recapitulating the Complex Three-Dimensional Organization.

ACS biomaterials science & engineering

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ACS biomaterials science & engineering

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