Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau.

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作者： Astrid,Wachter ^[1] ; Maya E,Woodbury ^[2] ; Sylvia,Lombardo ^[1] ; Aicha,Abdourahman ^[3] ; Carolin,Wuest ^[1] ; Emily,McGlame ^[3] ; Timothy,Pastika ^[3] ; Joseph,Tamm ^[3] ; Nandini,Romanul ^[3] ; Kiran,Yanamandra ^[3] ; Rachel,Bennett ^[4] ; Gen,Lin ^[5] ; Taekyung,Kwon ^[3] ; Fan,Liao ^[3] ; Corinna,Klein ^[1] ; Yelena,Grinberg ^[3] ; Methasit,Jaisa-Aad ^[4] ; Huan,Li ^[4] ; Matthew P,Frosch ^[6] ; Markus P,Kummer ^[1] ; Sudeshna,Das ^[6] ; Tammy,Dellovade ^[3] ; Eric H,Karran ^[3] ; Xavier,Langlois ^[3] ; Janina S,Ried ^[1] ; Alberto,Serrano-Pozo ^[6] ; Robert V,Talanian ^[3] ; Knut,Biber ^[1] ; Bradley T,Hyman ^[6]

作者单位： AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany. ^[1] AbbVie Inc., Cambridge, MA, USA. maya.woodbury@abbvie.com. ^[2] AbbVie Inc., Cambridge, MA, USA. ^[3] Massachusetts General Hospital, Boston, USA.;Harvard Medical School, Boston, USA. ^[4] AbbVie Pte Ltd, Singapore, Singapore. ^[5] Massachusetts General Hospital, Boston, USA.;Harvard Medical School, Boston, USA.;Massachusetts Alzheimer's Disease Research Center, Charlestown, USA. ^[6]

关键词 Alzheimer’s disease Microglia Myeloid cells Single-nucleus RNA-sequencing