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Atomically accurate de novo design of antibodies with RFdiffusion.

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第一作者: Nathaniel R,Bennett
第一单位: Department of Biochemistry, University of Washington, Seattle, WA, USA.;Institute for Protein Design, University of Washington, Seattle, WA, USA.;Graduate Program in Molecular Engineering, University of Washington, Seattle, WA, USA.
作者单位: Department of Biochemistry, University of Washington, Seattle, WA, USA.;Institute for Protein Design, University of Washington, Seattle, WA, USA.;Graduate Program in Molecular Engineering, University of Washington, Seattle, WA, USA. [1] Department of Biochemistry, University of Washington, Seattle, WA, USA.;Institute for Protein Design, University of Washington, Seattle, WA, USA. [2] Department of Biochemistry, University of Washington, Seattle, WA, USA.;Institute for Protein Design, University of Washington, Seattle, WA, USA.;Department of Bioengineering, University of Washington, Seattle, WA, USA. [3] Department of Biomedical Engineering, University of California; Irvine, CA, USA.;Center for Synthetic Biology, University of California; Irvine, CA, USA.;Department of Pharmaceutical Sciences, University of California; Irvine, CA, USA. [4] Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.;Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. [5] Department of Biochemistry, University of Washington, Seattle, WA, USA.;Institute for Protein Design, University of Washington, Seattle, WA, USA.;Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. [6] Molecular Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada. [7] Institute for Protein Design, University of Washington, Seattle, WA, USA. [8] Center for Biomolecular and Cellular Structure, Institute for Basic Science (IBS), Daejeon, 34126, Republic of Korea.;Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea. [9] Department of Biochemistry, University of Washington, Seattle, WA, USA.;Institute for Protein Design, University of Washington, Seattle, WA, USA.;Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA, USA. [10] Center for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.;Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA. [11] Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA. [12] Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.;Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA. [13] Molecular Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.;Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada. [14] Department of Biomedical Engineering, University of California; Irvine, CA, USA.;Center for Synthetic Biology, University of California; Irvine, CA, USA.;Department of Chemistry, University of California; Irvine, CA, USA.;Department of Molecular Biology & Biochemistry, University of California; Irvine, CA, USA. [15]
DOI 10.1101/2024.03.14.585103
PMID 38562682
发布时间 2026-03-06
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