Pharmacokinetics and multi-peak phenomenon analysis of novel anti-Parkinson's drug FLZ after multi-dose in cynomolgus monkeys.

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作者： Jiayu,Li ^[1] ; Shuofeng,Zhang ^[1] ; Rui,Chen ^[2]

作者单位： School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China. ^[1] Clinical Pharmacology Research Centre, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK and PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. ^[2]

关键词 FLZ MPTP-induced cynomolgus monkey anti-Parkinson drug multi-dose pharmacokinetics multi-peak absorption

主题词动物(Animals);成束猴(Macaca fascicularis);抗震颤麻痹药(Antiparkinson Agents);男(雄)性(Male);女(雌)性(Female);投药, 口服(Administration, Oral);剂量效应关系, 药物(Dose-Response Relationship, Drug)

DOI 10.1080/00498254.2024.2326475

PMID 38563808

发布时间 2024-04-30

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准确一般字义偏差语意偏离译文作用小提交