Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells.

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第一作者： Xin,Shen

第一单位： Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou 325035, China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: 1114239370@qq.com.

作者： Xin,Shen ^[1] ; Yiqun,Xia ^[2] ; Hui,Lu ^[3] ; Peisen,Zheng ^[4] ; Junqi,Wang ^[5] ; Yinghua,Chen ^[6] ; Chenxin,Xu ^[7] ; Chenyu,Qiu ^[8] ; Yafei,Zhang ^[9] ; Zhongxiang,Xiao ^[10] ; Peng,Zou ^[11] ; Ri,Cui ^[12] ; Daoyong,Ni ^[13]

作者单位： Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou 325035, China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: 1114239370@qq.com. ^[1] The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: yiqunxia@yeah.net. ^[2] School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: 2537701900@qq.com. ^[3] School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: 980406643@qq.com. ^[4] The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: 1427070675@qq.com. ^[5] School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: 1547765895@qq.com. ^[6] School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: 3240225953@qq.com. ^[7] School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: 309239716@qq.com. ^[8] School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: yafei_zhang1004@163.com. ^[9] Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: xiangzi198155@163.com. ^[10] Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou 325035, China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: zoupeng@wmu.edu.cn. ^[11] School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: wzmucuiri@163.com. ^[12] Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: daoyongni@163.com. ^[13]

关键词 AKT Autophagy Colon cancer ROS TrxR1

主题词人类(Humans);结肠肿瘤(Colonic Neoplasms);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);硫氧还蛋白还原酶1(Thioredoxin Reductase 1);药物协同作用(Drug Synergism);金诺芬(Auranofin);活性氧(Reactive Oxygen Species);信号传导(Signal Transduction);杂环化合物, 3环(Heterocyclic Compounds, 3-Ring);细胞系, 肿瘤(Cell Line, Tumor);磷酰化(Phosphorylation);吗啉类(Morpholines);HCT116细胞(HCT116 Cells);吡喃酮类(Pyrones)

DOI 10.1016/j.biopha.2024.116507

PMID 38565059

发布时间 2024-05-02

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024年174卷

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Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

相关期刊

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