The β-Secretase BACE1 Drives Fibroblast Activation in Systemic Sclerosis through the APP/β-Catenin/Notch Signaling Axis.

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第一作者： Christopher W,Wasson

第一单位： Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom.

作者： Christopher W,Wasson ^[1] ; Enrico,De Lorenzis ^[2] ; Eva M,Clavane ^[3] ; Rebecca L,Ross ^[1] ; Kieran A,Walker ^[1] ; Begoña,Caballero-Ruiz ^[1] ; Cristina,Antinozzi ^[4] ; Rebecca,Wells ^[1] ; Gemma,Migneco ^[5] ; Jane M Y,Brown ^[3] ; Samuel J,Turvey ^[3] ; Katie J,Simmons ^[6] ; Natalia A,Riobo-Del Galdo ^[7] ; Luigi,Di Luigi ^[4] ; Clive S,McKimmie ^[8] ; Francesco,Del Galdo ^[9] ; Paul J,Meakin ^[10]

作者单位： Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom. ^[1] Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom; Division of Rheumatology, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. ^[2] Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom. ^[3] Unit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Rome, Italy. ^[4] Department of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA. ^[5] School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom. ^[6] Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom; Leeds Institute of Medical Research, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom. ^[7] Leeds Institute of Medical Research, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom. ^[8] Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom; Scleroderma Programme, NIHR Leeds Musculoskeletal Biomedical Research Centre, Leeds, United Kingdom. Electronic address: f.delgaldo@leeds.ac.uk. ^[9] Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom. Electronic address: p.j.meakin@leeds.ac.uk. ^[10]

关键词 Autoimmunity Bace1 Fibrosis Notch Wnt