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Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

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第一作者： YiQing,Lü

第一单位： Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.;Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.;Department of Biology, Suffolk University, Boston, MA, 02108, USA.

作者： YiQing,Lü ^[1] ; Tiffany,Cho ^[2] ; Saptaparna,Mukherjee ^[3] ; Carmen Florencia,Suarez ^[4] ; Nicolas S,Gonzalez-Foutel ^[4] ; Ahmad,Malik ^[2] ; Sebastien,Martinez ^[5] ; Dzana,Dervovic ^[5] ; Robin Hyunseo,Oh ^[2] ; Ellen,Langille ^[2] ; Khalid N,Al-Zahrani ^[5] ; Lisa,Hoeg ^[5] ; Zhen Yuan,Lin ^[5] ; Ricky,Tsai ^[5] ; Geraldine,Mbamalu ^[5] ; Varda,Rotter ^[3] ; Patricia,Ashton-Prolla ^[6] ; Jason,Moffat ^[7] ; Lucia Beatriz,Chemes ^[4] ; Anne-Claude,Gingras ^[2] ; Moshe,Oren ^[3] ; Daniel,Durocher ^[2] ; Daniel,Schramek ^[8]

作者单位： Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.;Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.;Department of Biology, Suffolk University, Boston, MA, 02108, USA. ^[1] Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.;Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. ^[2] Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. ^[3] Instituto de Investigaciones Biotecnológicas (IIBiO-CONICET), Universidad Nacional de San Martín, Buenos Aires, Argentina. ^[4] Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada. ^[5] Departamento de Genética, Universidade Federal do Rio Grande do Sul and Serviço de Genetica Médica HCPA, Porto Alegre, Brasil. ^[6] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.;Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, M5S3G9, Canada.;Genetics and Genome Biology Program, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada. ^[7] Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada. schramek@lunenfeld.ca.;Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. schramek@lunenfeld.ca. ^[8]

关键词 Breast Cancer Fluorescence-based Stability Reporter Genome-wide CRISPR Screening Mutant p53 p53 Stability