首页> Frontiers in endocrinology> Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells.

Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells.

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第一作者： Seyed M,Ghiasi

第一单位： Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.;Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.;Development and Aging Program, and Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States.

作者： Seyed M,Ghiasi ^[1] ; Piero,Marchetti ^[2] ; Lorenzo,Piemonti ^[3] ; Jens H,Nielsen ^[4] ; Bo T,Porse ^[5] ; Thomas,Mandrup-Poulsen ^[4] ; Guy A,Rutter ^[6]

作者单位： Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.;Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.;Development and Aging Program, and Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States. ^[1] Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa, Pisa, Italy. ^[2] Diabetes Research Institute, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, Milano, Italy. ^[3] Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. ^[4] Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.;The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.;Danish Stem Cell Center (DanStem) Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. ^[5] Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom.;Centre Hospitalier de l'Université de Montréal (CHUM) Research Centre (CRCHUM) and Faculty of Medicine, University of Montreal, Montreal, QC, Canada.;Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. ^[6]

关键词 RNA decay RNA processing insulin secretion nonsense-mediated decay transcript β-cells