Molecular basis of hippopotamus ACE2 binding to SARS-CoV-2.

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第一作者： Ruirui,Yang

第一单位： College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.;CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.

作者： Ruirui,Yang ^[1] ; Pu,Han ^[2] ; Pengcheng,Han ^[3] ; Dedong,Li ^[4] ; Runchu,Zhao ^[5] ; Sheng,Niu ^[6] ; Kefang,Liu ^[2] ; Shihua,Li ^[2] ; Wen-Xia,Tian ^[6] ; George Fu,Gao ^[1]

作者单位： College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.;CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China. ^[1] CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China. ^[2] School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China. ^[3] CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.;College of Veterinary Medicine, China Agricultural University, Beijing, China. ^[4] CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.;Institute of Physical Science and Information Technology, Anhui University, Hefei, China. ^[5] College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China. ^[6]

关键词 ACE2 SARS-CoV-2 cross-species recognition cryo-EM structure hippopotamus receptor binding domain (RBD)spike (S)

主题词动物(Animals);人类(Humans);偶蹄目(Artiodactyla);结合部位(Binding Sites);冷冻电子显微镜检查(Cryoelectron Microscopy);蛋白质结合(Protein Binding)

DOI 10.1128/jvi.00451-24

PMID 38591877

发布时间 2025-01-04

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