Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects.

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第一作者： Assaf,Menachem

第一单位： Preclinical Development, Compugen Ltd., Holon, Israel.

作者： Assaf,Menachem ^[1] ; Zoya,Alteber ^[2] ; Gady,Cojocaru ^[3] ; Tal,Fridman Kfir ^[2] ; Dan,Blat ^[2] ; Olga,Leiderman ^[2] ; Moran,Galperin ^[2] ; Lital,Sever ^[2] ; Nadav,Cohen ^[2] ; Keren,Cohen ^[2] ; Roy Z,Granit ^[3] ; Sandra,Vols ^[3] ; Masha,Frenkel ^[2] ; Liron,Soffer ^[2] ; Karin,Meyer ^[2] ; Keren,Menachem ^[2] ; Hadas,Galon Tilleman ^[2] ; Dina,Morein ^[2] ; Itamar,Borukhov ^[3] ; Amir,Toporik ^[3] ; Michal,Perpinial Shahor ^[2] ; Evgeny,Tatirovsky ^[2] ; Aviram,Mizrachi ^[4] ; Adva,Levy-Barda ^[5] ; Eran,Sadot ^[6] ; Yulia,Strenov ^[5] ; Ram,Eitan ^[7] ; Ariella,Jakobson-Setton ^[5] ; Natalia,Yanichkin ^[8] ; Pierre,Ferre ^[5] ; Eran,Ophir ^[9]

作者单位： Preclinical Development, Compugen Ltd., Holon, Israel. ^[1] Research & Drug Discovery, Compugen Ltd., Holon, Israel. ^[2] Computational Discovery, Compugen Ltd., Holon, Israel. ^[3] Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel. ^[4] Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel. ^[5] Biobank, Department of pathology, Rabin Medical Center, Petah Tikva, Israel. ^[6] Department of Surgery, Rabin Medical Center, Petach Tikva, Israel. ^[7] Department of Pathology, Rabin Medical Center, Petah Tikva, Israel. ^[8] Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel. ^[9] Preclinical Development, Compugen Ltd., Toulouse, France. ^[10] Compugen Ltd., Holon, Israel. ^[11]

主题词动物(Animals);人类(Humans);白细胞介素18(Interleukin-18);小鼠(Mice);肿瘤微环境(Tumor Microenvironment);细胞系, 肿瘤(Cell Line, Tumor);杀伤细胞, 天然(Killer Cells, Natural);肿瘤(Neoplasms);淋巴细胞活化(Lymphocyte Activation);女(雌)性(Female);小鼠, 近交C57BL(Mice, Inbred C57BL);胞间信号肽类和蛋白质类(Intercellular Signaling Peptides and Proteins);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);T淋巴细胞(T-Lymphocytes)

DOI 10.1158/2326-6066.CIR-23-0706

PMID 38592331

发布时间 2024-06-07

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Cancer immunology research

2024年12卷6期

687-703页

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Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects.

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Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects.

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