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Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects.

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第一作者： Assaf,Menachem

第一单位： Preclinical Development, Compugen Ltd., Holon, Israel.

作者： Assaf,Menachem ^[1] ; Zoya,Alteber ^[2] ; Gady,Cojocaru ^[3] ; Tal,Fridman Kfir ^[2] ; Dan,Blat ^[2] ; Olga,Leiderman ^[2] ; Moran,Galperin ^[2] ; Lital,Sever ^[2] ; Nadav,Cohen ^[2] ; Keren,Cohen ^[2] ; Roy Z,Granit ^[3] ; Sandra,Vols ^[3] ; Masha,Frenkel ^[2] ; Liron,Soffer ^[2] ; Karin,Meyer ^[2] ; Keren,Menachem ^[2] ; Hadas,Galon Tilleman ^[2] ; Dina,Morein ^[2] ; Itamar,Borukhov ^[3] ; Amir,Toporik ^[3] ; Michal,Perpinial Shahor ^[2] ; Evgeny,Tatirovsky ^[2] ; Aviram,Mizrachi ^[4] ; Adva,Levy-Barda ^[5] ; Eran,Sadot ^[6] ; Yulia,Strenov ^[7] ; Ram,Eitan ^[8] ; Ariella,Jakobson-Setton ^[8] ; Natalia,Yanichkin ^[9] ; Pierre,Ferre ^[10] ; Eran,Ophir ^[11]

作者单位： Preclinical Development, Compugen Ltd., Holon, Israel. ^[1] Research & Drug Discovery, Compugen Ltd., Holon, Israel. ^[2] Computational Discovery, Compugen Ltd., Holon, Israel. ^[3] Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel.;Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel. ^[4] Biobank, Department of pathology, Rabin Medical Center, Petah Tikva, Israel. ^[5] Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.;Department of Surgery, Rabin Medical Center, Petach Tikva, Israel. ^[6] Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.;Department of Pathology, Rabin Medical Center, Petah Tikva, Israel. ^[7] Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.;Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel. ^[8] Department of Pathology, Rabin Medical Center, Petah Tikva, Israel. ^[9] Preclinical Development, Compugen Ltd., Toulouse, France. ^[10] Compugen Ltd., Holon, Israel. ^[11]

医学主题词人类(Humans);男(雄)性(Male);女(雌)性(Female);动物(Animals);小鼠(Mice);细胞系, 肿瘤(Cell Line, Tumor);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C57BL(Mice, Inbred C57BL);抗肿瘤药(Antineoplastic Agents);胞间信号肽类和蛋白质类(Intercellular Signaling Peptides and Proteins);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);共同培养技术(Coculture Techniques);白细胞介素18(Interleukin-18);肿瘤(Neoplasms);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);自然杀伤T细胞(Natural Killer T-Cells);抗体(Antibodies)

DOI 10.1158/2326-6066.CIR-23-0706

PMID 38592331

发布时间 2025-03-03

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Cancer immunology research

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Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects.

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Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects.

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