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Methods for non-proportional hazards in clinical trials: A systematic review.

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第一作者： Maximilian,Bardo

第一单位： Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.;Maximilian Bardo and Cynthia Huber contributed equally to this study.

作者： Maximilian,Bardo ^[1] ; Cynthia,Huber ^[1] ; Norbert,Benda ^[2] ; Jonas,Brugger ^[3] ; Tobias,Fellinger ^[4] ; Vaidotas,Galaune ^[5] ; Judith,Heinz ^[6] ; Harald,Heinzl ^[7] ; Andrew C,Hooker ^[5] ; Florian,Klinglmüller ^[4] ; Franz,König ^[3] ; Tim,Mathes ^[6] ; Martina,Mittlböck ^[7] ; Martin,Posch ^[3] ; Robin,Ristl ^[3] ; Tim,Friede ^[6]

作者单位： Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.;Maximilian Bardo and Cynthia Huber contributed equally to this study. ^[1] Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.;Federal Institute for Drugs and Medical Devices, Bonn, Germany. ^[2] Center for Medical Data Science, Section of Medical Statistics, Medical University of Vienna, Vienna, Austria. ^[3] Agentur für Gesundheit und Ernährungssicherheit (AGES), Vienna, Austria. ^[4] Department of Pharmacy, Uppsala University, Uppsala, Sweden. ^[5] Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany. ^[6] Center for Medical Data Science, Section of Clinical Biometrics, Medical University of Vienna, Vienna, Austria. ^[7]

关键词 Cox model log-rank test non-proportional hazards right-censored observations survival analysis

医学主题词人类(Humans);比例危险度模型(Proportional Hazards Models);临床试验(主题)(Clinical Trials as Topic);样本大小(Sample Size);软件(Software)

DOI 10.1177/09622802241242325

PMID 38592333

发布时间 2026-02-05

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