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Myeloid-T cell interplay and cell state transitions associated with checkpoint inhibitor response in melanoma.

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第一作者： Ramona,Schlenker

第一单位： Roche Innovation Center Munich, Roche Pharma Research and Early Development (pRED), Penzberg, Germany. Electronic address: ramona.schlenker@roche.com.

作者： Ramona,Schlenker ^[1] ; Petra C,Schwalie ^[2] ; Steffen,Dettling ^[3] ; Tamara,Huesser ^[4] ; Anja,Irmisch ^[5] ; Marisa,Mariani ^[4] ; Julia M,Martínez Gómez ^[5] ; Alison,Ribeiro ^[4] ; Florian,Limani ^[4] ; Sylvia,Herter ^[4] ; Emilio,Yángüez ^[4] ; Sabine,Hoves ^[3] ; Jitka,Somandin ^[4] ; Juliane,Siebourg-Polster ^[6] ; Tony,Kam-Thong ^[6] ; Ines Grazina,de Matos ^[4] ; Pablo,Umana ^[4] ; Reinhard,Dummer ^[5] ; Mitchell P,Levesque ^[5] ; Marina,Bacac ^[4]

作者单位： Roche Innovation Center Munich, Roche Pharma Research and Early Development (pRED), Penzberg, Germany. Electronic address: ramona.schlenker@roche.com. ^[1] Roche Innovation Center Basel, pRED, Basel, Switzerland. Electronic address: petra.schwalie@roche.com. ^[2] Roche Innovation Center Munich, Roche Pharma Research and Early Development (pRED), Penzberg, Germany. ^[3] Roche Innovation Center Zurich, pRED, Schlieren, Switzerland. ^[4] Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. ^[5] Roche Innovation Center Basel, pRED, Basel, Switzerland. ^[6]

关键词 T cell Translation to patients cancer immunotherapy immune checkpoint macrophage melanoma peripheral blood mononuclear cell single-cell RNA sequencing tumor microenvironment tumor-infiltrated lymphocyte