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Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease.

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第一作者: Prabesh,Bhattarai
第一单位: Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.;Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.
作者单位: Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.;Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA. [1] Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.;Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA. [2] Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.;NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA.;Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. [3] Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, 06520, USA. [4] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.;Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA. [5] Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20817, USA. [6] Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.;Quantitative Sciences Unit, Department of Medicine, Stanford University, Stanford, CA, USA. [7] Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.;Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.;Department of Medicine, College of Physicians and Surgeons, Columbia University New York, New York, USA. [8] School of Medicine, Pontificia Universidad Catolica Madre y Maestra, Santiago, Dominican Republic. [9] Department of Neurology, CEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic.;School of Medicine, Universidad Pedro Henriquez Urena (UNPHU), Santo Domingo, Dominican Republic. [10] Department of Neurology, CEDIMAT, Plaza de la Salud, Santo Domingo, Dominican Republic. [11] Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.;Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA. [12] Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.;Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.;Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA. [13] Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA. [14] Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. [15] Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.;The American Genome Center, Center for Military Precision Health, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. [16] New York Genome Center, New York, NY, 10013, USA. [17] Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA.;Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.;Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.;Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY, 10032, USA.;Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St., New York, NY, 10032, USA. [18] Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA. ck2893@cumc.columbia.edu.;Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA. ck2893@cumc.columbia.edu.;Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA. ck2893@cumc.columbia.edu. [19] Department of Neurology, Columbia University Irving Medical Center, Columbia University New York, New York, NY, USA. bnv2103@cumc.columbia.edu.;Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, NY, USA. bnv2103@cumc.columbia.edu.;Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA. bnv2103@cumc.columbia.edu. [20]
DOI 10.1007/s00401-024-02721-1
PMID 38598053
发布时间 2025-08-28
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