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DNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues.

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第一作者: Kian Hong,Kock
第一单位: Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.;Program in Biological and Biomedical Sciences, Harvard University, Cambridge, MA, USA.
作者单位: Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.;Program in Biological and Biomedical Sciences, Harvard University, Cambridge, MA, USA. [1] Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.;Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. [2] Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA. [3] Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.;Boston Bangalore Biosciences Beginnings Program, Harvard University, Cambridge, MA, USA. [4] Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.;Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA. [5] Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. [6] Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.;Committee on Higher Degrees in Biophysics, Harvard University, Cambridge, MA, USA. [7] Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.;Bioinformatics and Integrative Genomics Graduate Program, Harvard University, Cambridge, MA, USA. [8] Program in Biological and Biomedical Sciences, Harvard University, Cambridge, MA, USA.;Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.;Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.;Committee on Higher Degrees in Biophysics, Harvard University, Cambridge, MA, USA. [9] Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA. [10] Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA. mlbulyk@genetics.med.harvard.edu.;Program in Biological and Biomedical Sciences, Harvard University, Cambridge, MA, USA. mlbulyk@genetics.med.harvard.edu.;Committee on Higher Degrees in Biophysics, Harvard University, Cambridge, MA, USA. mlbulyk@genetics.med.harvard.edu.;Bioinformatics and Integrative Genomics Graduate Program, Harvard University, Cambridge, MA, USA. mlbulyk@genetics.med.harvard.edu.;Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. mlbulyk@genetics.med.harvard.edu. [11]
DOI 10.1038/s41467-024-47396-0
PMID 38600112
发布时间 2024-04-25
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