Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.

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作者： Frank,Adolf ^[1] ; Jiale,Du ^[2] ; Ellen A,Goodall ^[3] ; Richard M,Walsh ^[4] ; Shaun,Rawson ^[4] ; Susanne,von Gronau ^[5] ; J Wade,Harper ^[3] ; John,Hanna ^[6] ; Brenda A,Schulman ^[7]

作者单位： Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany. fadolf@biochem.mpg.de.;Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. fadolf@biochem.mpg.de. ^[1] Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.;Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. ^[2] Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.;Department of Cell Biology, Harvard Medical School, Boston, MA, USA. ^[3] Harvard Cryo-Electron Microscopy Center for Structural Biology, Harvard Medical School, Boston, MA, USA.;Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. ^[4] Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany. ^[5] Department of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. jwhanna@bwh.harvard.edu. ^[6] Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany. schulman@biochem.mpg.de.;Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. schulman@biochem.mpg.de. ^[7]

主题词人类(Humans);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);冷冻电子显微镜检查(Cryoelectron Microscopy);分子伴侣(Molecular Chaperones);模型, 分子(Models, Molecular);蛋白质构象(Protein Conformation)

DOI 10.1038/s41594-024-01268-9

PMID 38600324

发布时间 2024-09-09

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