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FOXO1 is a master regulator of memory programming in CAR T cells.

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作者单位: Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. [1] Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [2] Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. [3] Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [4] Department of Pathology, Stanford University, Stanford, CA, USA. [5] Department of Bioengineering, Stanford University, Stanford, CA, USA. [6] Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. [7] Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA. [8] Department of Genetics, Stanford University, Stanford, CA, USA. [9] Genentech, South San Francisco, CA, USA. [10] Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [11] Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [12] Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [13] Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA. [14] Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [15] Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. [16] Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. cmackall@stanford.edu. [17] Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. cmackall@stanford.edu. [18] Department of Pediatrics, Stanford University, Stanford, CA, USA. cmackall@stanford.edu. [19] Department of Medicine, Stanford University, Stanford, CA, USA. cmackall@stanford.edu. [20] Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. weberew@chop.edu. [21] Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. weberew@chop.edu. [22] Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. weberew@chop.edu. [23] Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA. weberew@chop.edu. [24] Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. weberew@chop.edu. [25] Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. weberew@chop.edu. [26]
DOI 10.1038/s41586-024-07300-8
PMID 38600391
发布时间 2024-05-08
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