USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF.

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作者： Anamarija,Jurisic ^[1] ; Pei-Ju,Sung ^[1] ; Mark,Wappett ^[1] ; Julien,Daubriac ^[2] ; Ian T,Lobb ^[1] ; Wei-Wei,Kung ^[1] ; Nyree,Crawford ^[1] ; Natalie,Page ^[1] ; Eamon,Cassidy ^[1] ; Stephanie,Feutren-Burton ^[1] ; J S Shane,Rountree ^[1] ; Matthew D,Helm ^[1] ; Colin R,O'Dowd ^[1] ; Richard D,Kennedy ^[1] ; Gerald,Gavory ^[1] ; Aaron N,Cranston ^[1] ; Daniel B,Longley ^[1] ; Xavier,Jacq ^[1] ; Timothy,Harrison ^[2]

作者单位： Almac Discovery Ltd., Health Science Building, Belfast, UK. ^[1] Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK. ^[2]

关键词 ADC‐159 CAFs DUBs HAUSP HIF‐1α IO TME USP7 VEGF deubiquitylating enzymes immune checkpoint inhibitors immune therapy neoangiogenesis tumour microenvironment

主题词人类(Humans);血管内皮生长因子A(Vascular Endothelial Growth Factor A);肿瘤(Neoplasms);新生血管化, 病理性(Neovascularization, Pathologic);成纤维细胞(Fibroblasts);肿瘤微环境(Tumor Microenvironment);CCAAT增强子结合蛋白类(CCAAT-Enhancer-Binding Proteins);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)

DOI 10.1002/ctm2.1648

PMID 38602256

发布时间 2024-04-17

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Clinical and translational medicine

2024年14卷4期

e1648页

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USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF.

Clinical and translational medicine

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Clinical and translational medicine

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USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF.

Clinical and translational medicine

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Clinical and translational medicine

相关期刊

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