Mechanistic insights into G-protein activation via phosphorylation mediated non-canonical pathway.

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第一作者： Kunal,Shewani

第一单位： Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhopal 462066, MP, India.

作者： Kunal,Shewani ^[1] ; Midhun K,Madhu ^[2] ; Rajesh K,Murarka ^[3]

作者单位： Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhopal 462066, MP, India. ^[1] Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhopal 462066, MP, India. ^[2] Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhopal 462066, MP, India. Electronic address: rkm@iiserb.ac.in. ^[3]

关键词 G-protein activation GDP unbinding Markov state model Molecular dynamics simulation RTK phosphorylation Well-tempered metadynamics

主题词磷酰化(Phosphorylation);鸟嘌呤核苷酸交换因子类(Guanine Nucleotide Exchange Factors);信号传导(Signal Transduction);GTP结合蛋白质类(GTP-Binding Proteins);酪氨酸(Tyrosine)

DOI 10.1016/j.bpc.2024.107234

PMID 38603989

发布时间 2024-04-22

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