NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks.

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作者： Liron,David ^[1] ; Jazlyn P,Borges ^[2] ; L Robert,Hollingsworth ^[1] ; Allen,Volchuk ^[3] ; Isabelle,Jansen ^[4] ; Evelyn,Garlick ^[4] ; Benjamin E,Steinberg ^[5] ; Hao,Wu ^[6]

作者单位： Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. ^[1] Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON, Canada. ^[2] Program in Cell Biology, Hospital for Sick Children, Toronto, ON, Canada. ^[3] Abberior Instruments GmbH, Göttingen, Germany. ^[4] Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON, Canada; Department of Anesthesia and Pain Medicine, Hospital for Sick Children, Toronto, ON, Canada; Department of Anesthesiology and Pain Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. ^[5] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. Electronic address: wu@crystal.harvard.edu. ^[6]

关键词 NINJ1 NINJ2 Ninjurin1 Ninjurin2 cryo-EM inflammasome inflammation lytic cell death plasma membrane rupture pyroptosis