Exploring the molecular mechanisms and shared gene signatures between celiac disease and ulcerative colitis based on bulk RNA and single-cell sequencing: Experimental verification.

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作者： Changshan,Wan ^[1] ; Tao,Ji ^[2] ; Liwei,Wang ^[1] ; Qiuyan,Wu ^[1] ; Qiuyu,Chen ^[3] ; Yali,Wang ^[1] ; Yaqian,Li ^[1] ; Fengming,He ^[4] ; Wentian,Liu ^[5] ; Weilong,Zhong ^[6] ; Bangmao,Wang ^[7]

作者单位： Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin 300052, China. ^[1] Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin 300052, China; Department of Gastroenterology, Linyi People's Hospital, Shandong 276000, China. ^[2] Department of Gastroenterology, Tianjin First Central Hospital of Tianjin Medical University, Tianjin 300192, China. ^[3] Department of Clinical Laboratory Medicine, Shanxi Medical University, Taiyuan 030600, Shanxi, China. ^[4] Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin 300052, China. Electronic address: tliu01@tmu.edu.cn. ^[5] Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin 300052, China. Electronic address: zhongweilong@tmu.edu.cn. ^[6] Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin 300052, China. Electronic address: mwang02@tmu.edu.cn. ^[7]

关键词 Celiac disease Immune response REG4 Shared gene Ulcerative colitis

主题词乳糜泻(Celiac Disease);结肠炎, 溃疡性(Colitis, Ulcerative);人类(Humans);单细胞分析(Single-Cell Analysis);基因表达谱(Gene Expression Profiling);序列分析, RNA(Sequence Analysis, RNA)

DOI 10.1016/j.intimp.2024.112059

PMID 38615385

发布时间 2024-05-11

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