Gentisic acid prevents colorectal cancer metastasis via blocking GPR81-mediated DEPDC5 degradation.

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第一作者： Guize,Feng

第一单位： Department of Pharmacology & the Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, China.

作者： Guize,Feng ^[1] ; Lijie,Zhang ^[2] ; Weilian,Bao ^[3] ; Jiahui,Ni ^[1] ; Yirui,Wang ^[4] ; Yuran,Huang ^[1] ; Jiaren,Lyv ^[3] ; Xinyue,Cao ^[1] ; Tongqing,Chen ^[1] ; Keyuan,You ^[1] ; Haroon,Khan ^[5] ; Xiaoyan,Shen ^[6]

作者单位： Department of Pharmacology & the Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, China. ^[1] Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. ^[2] Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, China. ^[3] Artificial Intelligence Innovation and Incubation (AI³) Institute, Fudan University, Shanghai, China. ^[4] Department of Pharmacy, Abdul Wali Khan University Mardan, Pakistan. ^[5] Department of Pharmacology & the Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai, China; Shanghai Fifth People's Hospital, Fudan University, Shanghai, China; Artificial Intelligence Innovation and Incubation (AI³) Institute, Fudan University, Shanghai, China; MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China. Electronic address: shxiaoy@fudan.edu.cn. ^[6]

关键词 CMA DEPDC5 EMT Gentisic acid mTOR

主题词动物(Animals);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);结直肠肿瘤(Colorectal Neoplasms);人类(Humans);小鼠(Mice);上皮-间质转化(Epithelial-Mesenchymal Transition);肺肿瘤(Lung Neoplasms);HCT116细胞(HCT116 Cells);信号传导(Signal Transduction);细胞系, 肿瘤(Cell Line, Tumor);男(雄)性(Male);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases)

DOI 10.1016/j.phymed.2024.155615

PMID 38615493

发布时间 2024-06-05

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Phytomedicine

2024年129卷

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Gentisic acid prevents colorectal cancer metastasis via blocking GPR81-mediated DEPDC5 degradation.

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Gentisic acid prevents colorectal cancer metastasis via blocking GPR81-mediated DEPDC5 degradation.

Phytomedicine

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Phytomedicine

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