Construct Phenylethanoid Glycosides Harnessing Biosynthetic Networks, Protein Engineering and One-Pot Multienzyme Cascades.

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作者： Mingju,Yao ^[1] ; Haotian,Wang ^[1] ; Zilong,Wang ^[1] ; Chenglin,Song ^[1] ; Xiaolin,Sa ^[1] ; Wei,Du ^[2] ; Min,Ye ^[3] ; Xue,Qiao ^[3]

作者单位： State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing, 100191, China. ^[1] Agilent Technologies, 3 Wangjing North Road, Beijing, 100102, China. ^[2] State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing, 100191, China.;Peking University-Yunnan Baiyao International Medical Research Center, 38 Xueyuan Road, Beijing, 100191, China. ^[3]

关键词 Biocatalysis Glycosyltransferase Multienzyme cascade Phenylethanoid glycosides Protein engineering

主题词糖苷类(Glycosides);蛋白质工程(Protein Engineering);糖基转移酶类(Glycosyltransferases);儿茶酚氧化酶(Catechol Oxidase)

DOI 10.1002/anie.202402546

PMID 38616162

发布时间 2024-07-30

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